Wednesday, June 15, 2011

XenotransplantationEven the name sounds sci-fi. Xenotransplantation is the process of taking organs from donor animals, and transplanting them to humans. It hasn't been successful in the past, but genetic engineering just might make it work.The idea isn't

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Even the name sounds sci-fi. Xenotransplantation is the process of taking organs from donor animals, and transplanting them to humans. It hasnt been successful in the past, but genetic engineering just might make it work.


The idea isnt a new one. Some of the first known operations were actually performed all the way back in 106. French surgeon Mathieu Jaboulay implanted a pigs kidney into one woman, and a goats liver into another. Both patients died.


Fast-forward to a world famous case. In 184 a team of surgeons implanted a baboon heart into an infant in desperate need of a new heart. Baby Fae died after 0 days but the idea didnt.


Why is the idea still being pursued? The alarming shortage of donor organs. Many people suffer for years, or even die, while waiting for a suitable donor organ. In order to increase the supply of organs available, science is trying to produce animal organs that wont be rejected by human bodies.


Order Custom XenotransplantationEven the name sounds sci-fi. Xenotransplantation is the process of taking organs from donor animals, and transplanting them to humans. It hasn't been successful in the past, but genetic engineering just might make it work.The idea isn't paper


Rejection is one of transplantations biggest hurdles. Whether the donor organ comes from a person or an animal, the recipients immune system is likely to reject it. To overcome that hurdle, genetic engineering can adjust the genetic makeup of donor animals, adding or subtracting specific genes, to make the organs compatible to humans.


In 00 PPL Therapeutics, the company that created Dolly the cloned sheep, announced new knock-out pigs. These cloned piglets had specific genes knocked-out - removed from their DNA. The genes produce a substance that guarantees rejection. Without the genes, the substance is gone, increasing the odds that the organ is accepted.


Critics of xenotransplantation charge that not nearly enough is known about the process. Viruses that are normally carried only by animals could cross the species boundaries causing problems for people. There are also serious ethical objections to the process. Should animals be bred as organ factories for humans?











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